1259 Clinical Outcomes of Vascularised Versus Free Regenerative Peripheral Nerve Interface in Upper Limb Neuromas: A Systematic Review

Abstract Aim To compare clinical outcomes of vascularised regenerative peripheral nerve interface (vRPNI) versus free (fRPNI) in upper limb neuromas. Method A systematic review on neuromas treated with either fRPNI or vRPNI was performed October 2022 accordance the PRISMA 2020 guidelines. PubMed search using term “RPNI” performed. Only papers results from patients who had undergone to were included; and laboratory excluded. Patient data collected include underlying aetiology, time interval RPNI procedure, as well mean patient age, post-operative follow-up period neuroma pain score reduction. Results Of 43 identified, only four fulfilled inclusion criteria. This provided for 32 where a total 83 RPNIs (22 vascularised) (43 prophylactically). The means duration pain, length reported follow-up, reduction scores 44.0 years, 1.4 12.2 months 51.3% respectively. Conclusions currently available support use both treatment extremity neuromas, after development symptoms prophylactically at surgery, despite heterogeneity inconsistencies reporting. Further studies are required form randomised control trials assess superiority (or not) vRPNI.